Ozone Injection Therapies

Harnessing Oxygen’s Power for Healing and Pain Relief

What Are Ozone Injection Therapies?

Ozone injection therapy involves delivering a carefully controlled mixture of medical-grade oxygen and ozone (O₃) directly into joints, muscles, or soft tissues. This therapy is used to stimulate healing, reduce inflammation, and relieve pain.

At Johnson Medical Center, ozone injections are integrated into regenerative and physical medicine programs to help patients recover from injuries, chronic inflammation, and musculoskeletal pain—without relying on long-term medications or surgery.

How Does It Work?

Ozone triggers a mild, localized oxidative stress that activates the body’s healing mechanisms. Once injected, ozone can:

  • Reduce inflammation and modulate immune response [1]
  • Increase antioxidant enzyme production to combat oxidative stress [2]
  • Enhance oxygen delivery to tissues by improving red blood cell flexibility [3]
  • Stimulate local stem cell activity and collagen regeneration [4]
  • Inactivate harmful pathogens (bacteria, viruses, and fungi) [5]

Ozone therapy can be applied to joints, tendons, ligaments, and soft tissues—often alongside regenerative injections like PRP, A2M, or Wharton’s Jelly.

Conditions We Treat with Ozone Injections

Ozone is effective for a range of orthopedic and pain-related conditions, including:

  • Osteoarthritis (knee, shoulder, hip, spine)
  • Tendinitis and bursitis
  • Plantar fasciitis
  • Chronic back or neck pain
  • Joint degeneration
  • Shingles-related pain
  • Soft tissue inflammation

It’s also used for trigger point therapy, helping deactivate painful muscle knots and improve mobility.

Technique & Safety

Ozone is injected in low, therapeutic concentrations, and when done properly, is very safe. At Johnson Medical Center:

  • We use ultrasound guidance when appropriate for precision and safety
  • Injections are administered in a sterile, controlled setting
  • Each dose is customized for the patient’s condition and tolerance
  • We follow international standards for medical ozone use

While ozone is not yet FDA-approved for specific conditions, its safety and effectiveness are widely supported in international literature and clinical practice [6].

What to Expect

  • Most sessions last 15–30 minutes
  • Mild soreness may occur at the injection site, resolving within 24–48 hours
  • Patients often notice improvement after just a few sessions, with cumulative benefits over time
  • No sedation or downtime is needed

Why We Use It

For many of our patients, ozone is a bridge between pain relief and regenerative healing. It prepares tissues for stem cell or PRP injections, enhances circulation, reduces infection risk, and supports long-term repair.

Sources

  1. https://www.mdpi.com/2218-273X/11/3/356
  2. https://www.frontiersin.org/articles/10.3389/fphys.2022.840623/full
  3. https://www.frontiersin.org/articles/10.3389/fneur.2023.1078111/full
  4. https://www.thelancet.com/journals/lanam/article/PIIS2667-193X%2824%2900134-0/fulltext
  5. https://health.clevelandclinic.org/ozone-therapy
  6. https://www.medicalnewstoday.com/articles/320759

 


Johnson Medical Center is fully committed to complying with all Florida state and FDA regulations. Our MSC therapies are offered under approved protocols to ensure patient safety and regulatory adherence.

Before treatment, our patients receive detailed information about the investigational nature of MSC therapies, including potential risks and benefits, as required by Florida law. We are committed to ensuring you make an informed decision about your care.

Our umbilical cord-derived MSC therapies are processed in facilities that comply with FDA’s current Good Manufacturing Practices (cGMP) and Florida state regulations, ensuring the highest standards of safety and quality.

THIS NOTICE MUST BE PROVIDED TO YOU UNDER FLORIDA LAW. This physician performs one or more regenerative and/or stem cell therapies that have not yet been approved by the United States Food and Drug Administration. You are encouraged to consult with your primary care provider before undergoing any stem cell therapy.